Phagocytosis, an unrecognized property of murine endothelial liver cells
AM Steffan, JL Gendrault, RS McCuskey… - Hepatology, 1986 - journals.lww.com
Impairment of the phagocytic capacities of Kupffer cells, as is found in Frog Virus 3 hepatitis
of mice, allows the endothelial liver cells to take up intravenously inoculated latex particles
of 1.0 μm diameter. In vitro experiments with cultivated endothelial cells isolated by
collagenase perfusion of the liver and purified by centrifugal elutriation demonstrate that
uptake occurs via a typical mechanism of phagocytosis involving pseudopodia. Ingestion of
latex is inhibited by incubation of the cells at 4 C and by treatment with cytochalasin B …
of mice, allows the endothelial liver cells to take up intravenously inoculated latex particles
of 1.0 μm diameter. In vitro experiments with cultivated endothelial cells isolated by
collagenase perfusion of the liver and purified by centrifugal elutriation demonstrate that
uptake occurs via a typical mechanism of phagocytosis involving pseudopodia. Ingestion of
latex is inhibited by incubation of the cells at 4 C and by treatment with cytochalasin B …
