[HTML][HTML] Tetranor PGDM, an abundant urinary metabolite reflects biosynthesis of prostaglandin D2 in mice and humans
Prostaglandin D 2 (PGD 2) is a cyclooxygenase (COX) product of arachidonic acid that
activates D prostanoid receptors to modulate vascular, platelet, and leukocyte function in
vitro. However, little is known about its enzymatic origin or its formation in vivo in
cardiovascular or inflammatory disease. 11, 15-Dioxo-9α-hydroxy-2, 3, 4, 5-tetranorprostan-
1, 20-dioic acid (tetranor PGDM) was identified by mass spectrometry as a metabolite of
infused PGD 2 that is detectable in mouse and human urine. Using liquid chromatography …
activates D prostanoid receptors to modulate vascular, platelet, and leukocyte function in
vitro. However, little is known about its enzymatic origin or its formation in vivo in
cardiovascular or inflammatory disease. 11, 15-Dioxo-9α-hydroxy-2, 3, 4, 5-tetranorprostan-
1, 20-dioic acid (tetranor PGDM) was identified by mass spectrometry as a metabolite of
infused PGD 2 that is detectable in mouse and human urine. Using liquid chromatography …
