Comparison of the effects of prostacyclin (PGI2), prostaglandin E1 and D2 on platelet aggregation in different species
BJR Whittle, S Moncada, JR Vane - Prostaglandins, 1978 - Elsevier
The activity of prostacyclin (PGI 2), PGE 1 or PGD 2 as inhibitors of platelet aggregation in
plasma from human, dog, rabbit, rat, sheep and horse was investigated. Prostacyclin was
the most potent inhibitor in all species. PGD 2 was a weak inhibitor in dog, rabbit and rat
plasma whereas PGE 1 and prostacyclin were highly active. Theophylline or dipyridamole
potentiated the inhibition of human platelet aggregation by prostacyclin, PGE 1 or PGD 2.
Compound N-0164 abolished the inhibition by PGD 2 of human platelet aggregation but did …
plasma from human, dog, rabbit, rat, sheep and horse was investigated. Prostacyclin was
the most potent inhibitor in all species. PGD 2 was a weak inhibitor in dog, rabbit and rat
plasma whereas PGE 1 and prostacyclin were highly active. Theophylline or dipyridamole
potentiated the inhibition of human platelet aggregation by prostacyclin, PGE 1 or PGD 2.
Compound N-0164 abolished the inhibition by PGD 2 of human platelet aggregation but did …