Age of transfused blood is an independent risk factor for postinjury multiple organ failure
G Zallen, PJ Offner, EE Moore, J Blackwell… - The American journal of …, 1999 - Elsevier
Background: Blood transfusion has repeatedly been demonstrated to be an independent
risk factor for postinjury multiple organ failure (MOF). Previously believed to represent a
surrogate for shock, packed red blood cell (PRBC) transfusion has recently been shown to
result in neutrophil priming and pulmonary endothelial cell activation. We have previously
observed that the generation of inflammatory mediators is related to the length of PRBC unit
storage. The purpose of this study was to determine if age of transfused PRBC is a risk factor …
risk factor for postinjury multiple organ failure (MOF). Previously believed to represent a
surrogate for shock, packed red blood cell (PRBC) transfusion has recently been shown to
result in neutrophil priming and pulmonary endothelial cell activation. We have previously
observed that the generation of inflammatory mediators is related to the length of PRBC unit
storage. The purpose of this study was to determine if age of transfused PRBC is a risk factor …