Akt1/PKBα protects PC12 cells against the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium and reduces the levels of oxygen-free radicals
M Salinas, D Martı́n, A Alvarez, A Cuadrado - Molecular and Cellular …, 2001 - Elsevier
The phosphatidylinositol (PI)-3 kinase-Akt/PKB survival pathway protects neurons from
apoptosis caused by diverse stress stimuli. However, its protective effect against neurotoxins
that produce oxidative stress and neurodegeneration has not been investigated. We
analyzed the effect of this pathway on the action of the parkinsonism-inducing neurotoxin 1-
methyl-4-phenylpyridinium (MPP+). Overexpression of a membrane-targeted, N-myristylated
fusion protein of enhanced green fluorescence protein (EGFP) and mouse Akt1 attenuated …
apoptosis caused by diverse stress stimuli. However, its protective effect against neurotoxins
that produce oxidative stress and neurodegeneration has not been investigated. We
analyzed the effect of this pathway on the action of the parkinsonism-inducing neurotoxin 1-
methyl-4-phenylpyridinium (MPP+). Overexpression of a membrane-targeted, N-myristylated
fusion protein of enhanced green fluorescence protein (EGFP) and mouse Akt1 attenuated …
