Hepatocyte nuclear factor 1α plays a critical role in PCSK9 gene transcription and regulation by the natural hypocholesterolemic compound berberine
H Li, B Dong, SW Park, HS Lee, W Chen… - Journal of Biological …, 2009 - ASBMB
PCSK9 is a natural inhibitor of LDL receptor (LDLR) that binds the extracellular domain of
LDLR and triggers its intracellular degradation. PCSK9 and LDLR are coordinately
regulated at the transcriptional level by sterols through their promoter-imbedded sterol
response elements (SRE) and co-induced by statins. Identification of regulatory networks
modulating PCSK9 transcription is important for developing selective repressors of PCSK9
to improve statin efficacy by prolonging the up-regulation of LDLR. Interestingly, the plant …
LDLR and triggers its intracellular degradation. PCSK9 and LDLR are coordinately
regulated at the transcriptional level by sterols through their promoter-imbedded sterol
response elements (SRE) and co-induced by statins. Identification of regulatory networks
modulating PCSK9 transcription is important for developing selective repressors of PCSK9
to improve statin efficacy by prolonging the up-regulation of LDLR. Interestingly, the plant …
