Molecular mechanism of convergent regulation of brain Na+ channels by protein kinase C and protein kinase A anchored to AKAP-15
AR Cantrell, VC Tibbs, HY Frank, BJ Murphy… - Molecular and Cellular …, 2002 - Elsevier
Activation of D1-like dopamine (DA) receptors reduces peak Na+ current in hippocampal
neurons voltage-dependent in a manner via phosphorylation of the α subunit. This
modulation is dependent upon activation of cAMP-dependent protein kinase (PKA) and
requires phosphorylation of serine 573 (S573) in the intracellular loop connecting
homologous domains I and II (LI-II) by PKA anchored to A kinase anchoring protein-15
(AKAP-15). Activation of protein kinase C (PKC) also reduces peak Na+ currents and …
neurons voltage-dependent in a manner via phosphorylation of the α subunit. This
modulation is dependent upon activation of cAMP-dependent protein kinase (PKA) and
requires phosphorylation of serine 573 (S573) in the intracellular loop connecting
homologous domains I and II (LI-II) by PKA anchored to A kinase anchoring protein-15
(AKAP-15). Activation of protein kinase C (PKC) also reduces peak Na+ currents and …