[HTML][HTML] From the cover: protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1)
G Bhave, HJ Hu, KS Glauner, W Zhu… - Proceedings of the …, 2003 - ncbi.nlm.nih.gov
Protein kinase C (PKC) modulates the function of the capsaicin receptor transient receptor
potential vanilloid 1 (TRPV1). This modulation manifests as increased current when the
channel is activated by capsaicin. In addition, studies have suggested that phosphorylation
by PKC might directly gate the channel, because PKC-activating phorbol esters induce
TRPV1 currents in the absence of applied ligands. To test whether PKC both modulates and
gates the TRPV1 function by direct phosphorylation, we used direct sequencing to …
potential vanilloid 1 (TRPV1). This modulation manifests as increased current when the
channel is activated by capsaicin. In addition, studies have suggested that phosphorylation
by PKC might directly gate the channel, because PKC-activating phorbol esters induce
TRPV1 currents in the absence of applied ligands. To test whether PKC both modulates and
gates the TRPV1 function by direct phosphorylation, we used direct sequencing to …
Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1)
G Bhave, HJ Hu, KS Glauner, W Zhu… - Proceedings of the …, 2003 - National Acad Sciences
Protein kinase C (PKC) modulates the function of the capsaicin receptor transient receptor
potential vanilloid 1 (TRPV1). This modulation manifests as increased current when the
channel is activated by capsaicin. In addition, studies have suggested that phosphorylation
by PKC might directly gate the channel, because PKC-activating phorbol esters induce
TRPV1 currents in the absence of applied ligands. To test whether PKC both modulates and
gates the TRPV1 function by direct phosphorylation, we used direct sequencing to …
potential vanilloid 1 (TRPV1). This modulation manifests as increased current when the
channel is activated by capsaicin. In addition, studies have suggested that phosphorylation
by PKC might directly gate the channel, because PKC-activating phorbol esters induce
TRPV1 currents in the absence of applied ligands. To test whether PKC both modulates and
gates the TRPV1 function by direct phosphorylation, we used direct sequencing to …