[HTML][HTML] Identification of a novel integrin αMβ2 binding site in CCN1 (CYR61), a matricellular protein expressed in healing wounds and atherosclerotic lesions
JM Schober, LF Lau, TP Ugarova, SCT Lam - Journal of Biological …, 2003 - ASBMB
CCN1 (cysteine-rich 61) and CCN2 (connective tissue growth factor) are growth factor-
inducible immediate-early gene products found in atherosclerotic lesions, restenosed blood
vessels, and healing cutaneous wounds. Both CCN proteins have been shown to support
cell adhesion and induce cell migration through interaction with integrin receptors. Recently,
we have identified integrin α M β 2 as the major adhesion receptor mediating monocyte
adhesion to CCN1 and CCN2 and have shown that the α MI domain binds specifically to …
inducible immediate-early gene products found in atherosclerotic lesions, restenosed blood
vessels, and healing cutaneous wounds. Both CCN proteins have been shown to support
cell adhesion and induce cell migration through interaction with integrin receptors. Recently,
we have identified integrin α M β 2 as the major adhesion receptor mediating monocyte
adhesion to CCN1 and CCN2 and have shown that the α MI domain binds specifically to …