Multiple myeloma (MM) is a neoplasm of a terminally differentiated B-cell. The disease is
progressive and always lethal characterized by the slow proliferation of malignant plasma
cells in the bone marrow. Much of our current understanding of the biology of MM has been
obtained by studying MM-derived cell lines. Human myeloma cell lines were shown to be
suitable model systems for use in various fields of the biological sciences. However, it has
proved very difficult to establish cell lines from plasma cell dyscrasias. Most reported MM cell …