Pathophysiology of myeloma bone disease
FR Esteve, GD Roodman - Best practice & research Clinical haematology, 2007 - Elsevier
Multiple myeloma is a tumor of terminally differentiated plasma cells that home to and
expand in the bone marrow. It is the second most common hematologic malignancy, with
approximately 16,000 new cases per year, and accounts for an estimated 11,000 deaths in
the USA. It is the most common cancer to metastasize to bone, with up to 90% of patients
developing bone lesions. The bone lesions are purely osteolytic in nature, and up to 60% of
patients develop a pathologic fracture over the course of their disease. Bone disease is a …
expand in the bone marrow. It is the second most common hematologic malignancy, with
approximately 16,000 new cases per year, and accounts for an estimated 11,000 deaths in
the USA. It is the most common cancer to metastasize to bone, with up to 90% of patients
developing bone lesions. The bone lesions are purely osteolytic in nature, and up to 60% of
patients develop a pathologic fracture over the course of their disease. Bone disease is a …
