[HTML][HTML] Increased bone mass in mice after single injection of anti-receptor activator of nuclear factor-κB ligand-neutralizing antibody: evidence for bone anabolic effect …
Y Furuya, K Mori, T Ninomiya, Y Tomimori… - Journal of Biological …, 2011 - ASBMB
Receptor activator of nuclear factor-κB ligand (RANKL) is a pivotal osteoclast differentiation
factor. To investigate the effect of RANKL inhibition in normal mice, we prepared an anti-
mouse RANKL-neutralizing monoclonal antibody (Mab, clone OYC1) and established a new
mouse model with high bone mass induced by administration of OYC1. A single
subcutaneous injection of 5 mg/kg OYC1 in normal mice significantly augmented the bone
mineral density in the distal femoral metaphysis from day 2 to day 28. The OYC1 treatment …
factor. To investigate the effect of RANKL inhibition in normal mice, we prepared an anti-
mouse RANKL-neutralizing monoclonal antibody (Mab, clone OYC1) and established a new
mouse model with high bone mass induced by administration of OYC1. A single
subcutaneous injection of 5 mg/kg OYC1 in normal mice significantly augmented the bone
mineral density in the distal femoral metaphysis from day 2 to day 28. The OYC1 treatment …
