RNA interference in the clinic: challenges and future directions
Inherent difficulties with blocking many desirable targets using conventional approaches
have prompted many to consider using RNA interference (RNAi) as a therapeutic approach.
Although exploitation of RNAi has immense potential as a cancer therapeutic, many
physiological obstacles stand in the way of successful and efficient delivery. This Review
explores current challenges to the development of synthetic RNAi-based therapies and
considers new approaches to circumvent biological barriers, to avoid intolerable side effects …
have prompted many to consider using RNA interference (RNAi) as a therapeutic approach.
Although exploitation of RNAi has immense potential as a cancer therapeutic, many
physiological obstacles stand in the way of successful and efficient delivery. This Review
explores current challenges to the development of synthetic RNAi-based therapies and
considers new approaches to circumvent biological barriers, to avoid intolerable side effects …
Abstract
Inherent difficulties with blocking many desirable targets using conventional approaches have prompted many to consider using RNA interference (RNAi) as a therapeutic approach. Although exploitation of RNAi has immense potential as a cancer therapeutic, many physiological obstacles stand in the way of successful and efficient delivery. This Review explores current challenges to the development of synthetic RNAi-based therapies and considers new approaches to circumvent biological barriers, to avoid intolerable side effects and to achieve controlled and sustained release.
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