Incorporation of HLA-DR into the envelope of human immunodeficiency virus type 1 in vivo: correlation with stage of disease and presence of opportunistic infection
Human immunodeficiency virus type 1 (HIV-1) bearing HLA-DR in its envelope was detected
in plasma from all patients with chronic HIV-1 infection (n= 16) and was present at higher
levels in patients with active tuberculosis coinfection (n= 6). Intriguingly, however, HLA-DR
was not detectable in HIV-1 from patients during primary viremia (n= 6), suggesting the
possibility of virus replication in less-activated cells.
in plasma from all patients with chronic HIV-1 infection (n= 16) and was present at higher
levels in patients with active tuberculosis coinfection (n= 6). Intriguingly, however, HLA-DR
was not detectable in HIV-1 from patients during primary viremia (n= 6), suggesting the
possibility of virus replication in less-activated cells.
Abstract
Human immunodeficiency virus type 1 (HIV-1) bearing HLA-DR in its envelope was detected in plasma from all patients with chronic HIV-1 infection (n = 16) and was present at higher levels in patients with active tuberculosis coinfection (n = 6). Intriguingly, however, HLA-DR was not detectable in HIV-1 from patients during primary viremia (n = 6), suggesting the possibility of virus replication in less-activated cells.
American Society for Microbiology