[PDF][PDF] Wnt/β-catenin—a canonical tale of cell-fate choice in the vertebrate skeleton
E Kolpakova, BR Olsen - Developmental Cell, 2005 - cell.com
E Kolpakova, BR Olsen
Developmental Cell, 2005•cell.comThree exciting papers in this issue of Developmental Cell provide new insights into the
regulation of chondrocytic, osteoblastic, and osteoclastic differentiation during skeletal
development and postnatal growth. The studies demonstrate that Wnt/β-catenin signaling
represents both a mechanism in mesenchymal precursor cells for selecting between
chondrocytic and osteoblastic fates as well as a mechanism in osteoblasts for stimulating the
production of an inhibitor of osteoclast formation.
regulation of chondrocytic, osteoblastic, and osteoclastic differentiation during skeletal
development and postnatal growth. The studies demonstrate that Wnt/β-catenin signaling
represents both a mechanism in mesenchymal precursor cells for selecting between
chondrocytic and osteoblastic fates as well as a mechanism in osteoblasts for stimulating the
production of an inhibitor of osteoclast formation.
Three exciting papers in this issue of Developmental Cell provide new insights into the regulation of chondrocytic, osteoblastic, and osteoclastic differentiation during skeletal development and postnatal growth. The studies demonstrate that Wnt/β-catenin signaling represents both a mechanism in mesenchymal precursor cells for selecting between chondrocytic and osteoblastic fates as well as a mechanism in osteoblasts for stimulating the production of an inhibitor of osteoclast formation.
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