Synapse disassembly and formation of new synapses in postnatal muscle upon conditional inactivation of MuSK
BA Hesser, O Henschel, V Witzemann - Molecular and Cellular …, 2006 - Elsevier
The muscle-specific-kinase MuSK is required for the formation of acetylcholine receptor
clusters during embryonic development, but its physiological role in adult muscle is not
known. We used the loxP/Cre system in mice to conditionally inactivate MuSK whereby
expression of Cre recombinase increases during postnatal development. The MuSK-
inactivated mice develop myasthenic symptoms and die prematurely due to severe muscle
weakness. The postnatal inactivation of MuSK causes loss of acetylcholine receptors and …
clusters during embryonic development, but its physiological role in adult muscle is not
known. We used the loxP/Cre system in mice to conditionally inactivate MuSK whereby
expression of Cre recombinase increases during postnatal development. The MuSK-
inactivated mice develop myasthenic symptoms and die prematurely due to severe muscle
weakness. The postnatal inactivation of MuSK causes loss of acetylcholine receptors and …