[HTML][HTML] Regulation of the NF-κB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation
The NF-κB family of transcription factors plays a pivotal role in regulation of diverse
biological processes, including immune responses, cell growth, and apoptosis. Activation of
NF-κB is mediated by both canonical and noncanonical signaling pathways. Although the
canonical pathway has been extensively studied, the mechanism mediating the
noncanonical pathway is still poorly understood. Recent studies have identified the NF-κB-
inducing kinase (NIK) as a key component of the noncanonical pathway of NF-κB activation; …
biological processes, including immune responses, cell growth, and apoptosis. Activation of
NF-κB is mediated by both canonical and noncanonical signaling pathways. Although the
canonical pathway has been extensively studied, the mechanism mediating the
noncanonical pathway is still poorly understood. Recent studies have identified the NF-κB-
inducing kinase (NIK) as a key component of the noncanonical pathway of NF-κB activation; …
