[HTML][HTML] Inhibition of the mitogen-activated protein kinase pathway triggers B16 melanoma cell differentiation
In B16 melanoma cells, mitogen-activated protein (MAP) kinases are activated during cAMP-
induced melanogenesis (Englaro, W., Rezzonico, R., Durand-Clément, M., Lallemand, D.,
Ortonne, JP, and Ballotti, R.(1995) J. Biol. Chem. 270, 24315–24320). To establish the role
of the MAP kinases in melanogenesis, we studied the effects of a specific MAP kinase
kinase (MEK) inhibitor PD 98059 on different melanogenic parameters. We showed that PD
98059 inhibits the activation of MAP kinase extracellular signal-regulated kinase 1 by cAMP …
induced melanogenesis (Englaro, W., Rezzonico, R., Durand-Clément, M., Lallemand, D.,
Ortonne, JP, and Ballotti, R.(1995) J. Biol. Chem. 270, 24315–24320). To establish the role
of the MAP kinases in melanogenesis, we studied the effects of a specific MAP kinase
kinase (MEK) inhibitor PD 98059 on different melanogenic parameters. We showed that PD
98059 inhibits the activation of MAP kinase extracellular signal-regulated kinase 1 by cAMP …