[HTML][HTML] Heparin-induced leukocytosis requires 6-O-sulfation and is caused by blockade of selectin-and CXCL12 protein-mediated leukocyte trafficking in mice
S Zhang, E Condac, H Qiu, J Jiang… - Journal of Biological …, 2012 - ASBMB
Leukocytosis refers to an increase in leukocyte count above the normal range in the blood
and is a common laboratory finding in patients. In many cases, the mechanisms underlying
leukocytosis are not known. In this study, we examined the effects, the structural
determinants, and the underlying mechanisms of heparin-induced leukocytosis, a side effect
occurring in 0.44% of patients receiving heparin. We observed that heparin induced both
lymphocytosis and neutrophilia, and the effects required heparin to be 6-O-sulfated but did …
and is a common laboratory finding in patients. In many cases, the mechanisms underlying
leukocytosis are not known. In this study, we examined the effects, the structural
determinants, and the underlying mechanisms of heparin-induced leukocytosis, a side effect
occurring in 0.44% of patients receiving heparin. We observed that heparin induced both
lymphocytosis and neutrophilia, and the effects required heparin to be 6-O-sulfated but did …