Protective effects of glutathione on cisplatin neurotoxicity in rats
G Cavaletti, C Minoia, M Schieppati, G Tredici - International Journal of …, 1994 - Elsevier
Purpose: Different attempts have been made to minimize the neurotoxicity of cisplatin (DDP)
and the use of “neuroprotective” drugs seems to be a promising strategy. In rats we
compared the effects on the dorsal root ganglia neurons and peripheral nerves of the
administration of DDP alone or in combination with glutathione (GSH), a putative
“neuroprotective” drug. Methods and Materials: Twenty-four Wistar rats were treated with
DDP alone (2 mg/kg/week) or with the same dose of DDP plus GSH (300 mg/week) for nine …
and the use of “neuroprotective” drugs seems to be a promising strategy. In rats we
compared the effects on the dorsal root ganglia neurons and peripheral nerves of the
administration of DDP alone or in combination with glutathione (GSH), a putative
“neuroprotective” drug. Methods and Materials: Twenty-four Wistar rats were treated with
DDP alone (2 mg/kg/week) or with the same dose of DDP plus GSH (300 mg/week) for nine …