[HTML][HTML] The leucine zipper of NRL interacts with the CRX homeodomain: a possible mechanism of transcriptional synergy in rhodopsin regulation
Photoreceptor-specific expression of rhodopsin is mediated by multiple cis-acting elements
in the proximal promoter region. NRL (neural retina leucine zipper) and CRX (cone rod
homeobox) proteins bind to the adjacent NRE and Ret-4 sites, respectively, within this
region. Although NRL and CRX are each individually able to induce rhodopsin promoter
activity, when expressed together they exhibit transcriptional synergy in rhodopsin promoter
activation. Using the yeast two-hybrid method and glutathione S-transferase pull-down …
in the proximal promoter region. NRL (neural retina leucine zipper) and CRX (cone rod
homeobox) proteins bind to the adjacent NRE and Ret-4 sites, respectively, within this
region. Although NRL and CRX are each individually able to induce rhodopsin promoter
activity, when expressed together they exhibit transcriptional synergy in rhodopsin promoter
activation. Using the yeast two-hybrid method and glutathione S-transferase pull-down …