Uptake and degradation of low density lipoprotein by swine arterial smooth muscle cells with inhibition of cholesterol biosynthesis
DB Weinstein, TE Carew, D Steinberg - Biochimica et Biophysica Acta (BBA …, 1976 - Elsevier
We have previously proposed on the basis of studies in hepatectomized animals that low
density lipoproteins are degraded at a significant rate by peripheral tissues. To test the
capacity of one peripheral cell type to catabolize low density lipoprotein, cultures of swine
aortic smooth muscle cells were incubated with homologous 125 I-labeled low density
lipoprotein and uptake and degradation measured. Degradation of 125 I-labeled low density
lipoprotein to products soluble in trichloroacetic acid showed an initial lag period of 1–2 h …
density lipoproteins are degraded at a significant rate by peripheral tissues. To test the
capacity of one peripheral cell type to catabolize low density lipoprotein, cultures of swine
aortic smooth muscle cells were incubated with homologous 125 I-labeled low density
lipoprotein and uptake and degradation measured. Degradation of 125 I-labeled low density
lipoprotein to products soluble in trichloroacetic acid showed an initial lag period of 1–2 h …