A surgical model to study in vivo efflux of cholesterol from porcine aorta evidence for cholesteryl ester transfer through the aortic wall
E Hjelms, BG Nordestgaard, S Stender, K Kjeldsen - Atherosclerosis, 1989 - Elsevier
We describe a surgical procedure in pigs which makes it possible to follow the influx into, the
penetration through and the efflux from the arterial wall of labeled lipoproteins. After 4 h
exposure of the luminal side of the arterial wall to labeled lipoproteins, labeled esterified
cholesterol was found in all layers of the aortic wall, whereas labeled free cholesterol gained
access only to the most luminal layer. The data suggest that at least 40%, if not 80–90%, of
the cholesteryl ester that enters the aortic wall from the luminal side, passes through the …
penetration through and the efflux from the arterial wall of labeled lipoproteins. After 4 h
exposure of the luminal side of the arterial wall to labeled lipoproteins, labeled esterified
cholesterol was found in all layers of the aortic wall, whereas labeled free cholesterol gained
access only to the most luminal layer. The data suggest that at least 40%, if not 80–90%, of
the cholesteryl ester that enters the aortic wall from the luminal side, passes through the …