Milroy disease and the VEGFR-3 mutation phenotype

G Brice, AH Child, A Evans, R Bell… - Journal of medical …, 2005 - jmg.bmj.com
G Brice, AH Child, A Evans, R Bell, S Mansour, K Burnand, M Sarfarazi, S Jeffery, P Mortimer
Journal of medical genetics, 2005jmg.bmj.com
Primary congenital lymphoedema (Milroy disease) is a rare autosomal dominant condition
for which a major causative gene defect has recently been determined. Mutations in the
vascular endothelial growth factor receptor 3 (VEGFR-3) gene have now been described in
13 families world-wide. This is a review of the condition based on the clinical findings in 71
subjects from 10 families. All 71 individuals have a mutation in VEGFR-3. Ninety per cent of
the 71 individuals carrying a VEGFR-3 mutation showed signs of oedema, which was …
Primary congenital lymphoedema (Milroy disease) is a rare autosomal dominant condition for which a major causative gene defect has recently been determined. Mutations in the vascular endothelial growth factor receptor 3 (VEGFR-3) gene have now been described in 13 families world-wide. This is a review of the condition based on the clinical findings in 71 subjects from 10 families. All 71 individuals have a mutation in VEGFR-3. Ninety per cent of the 71 individuals carrying a VEGFR-3 mutation showed signs of oedema, which was confined in all cases to the lower limbs. In all but two cases onset of swelling was from birth. Other symptoms and signs included cellulitis (20%), large calibre leg veins (23%), papillomatosis (10%), and upslanting toenails (10%). In males, hydrocoele was the next most common finding after oedema (37%). Thorough clinical examination of these patients indicates that there are few clinical signs in addition to lower limb oedema. Rigorous phenotyping of patients produces a high yield of VEGFR-3 mutations.
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