Genetic tracing of the gustatory and trigeminal neural pathways originating from T1R3-expressing taste receptor cells and solitary chemoreceptor cells
M Ohmoto, I Matsumoto, A Yasuoka… - Molecular and Cellular …, 2008 - Elsevier
We established transgenic mouse lines expressing a transneuronal tracer, wheat germ
agglutinin (WGA), under the control of mouse T1R3 gene promoter/enhancer. In the taste
buds, WGA transgene was faithfully expressed in T1R3-positive sweet/umami taste receptor
cells. WGA protein was transferred not laterally to the synapse-bearing, sour-responsive
type III cells in the taste buds but directly to a subset of neurons in the geniculate and
nodose/petrosal ganglia, and further conveyed to a rostro-central region of the nucleus of …
agglutinin (WGA), under the control of mouse T1R3 gene promoter/enhancer. In the taste
buds, WGA transgene was faithfully expressed in T1R3-positive sweet/umami taste receptor
cells. WGA protein was transferred not laterally to the synapse-bearing, sour-responsive
type III cells in the taste buds but directly to a subset of neurons in the geniculate and
nodose/petrosal ganglia, and further conveyed to a rostro-central region of the nucleus of …
