Anti-phospholipase A2 receptor antibody in membranous nephropathy
W Qin, LH Beck Jr, C Zeng, Z Chen, S Li… - Journal of the …, 2011 - journals.lww.com
The M-type phospholipase A2 receptor (PLA2R) is a target autoantigen in adult idiopathic
membranous nephropathy (MN), but the prevalence of autoantibodies against PLA2R is
unknown among Chinese patients with MN. Here, we measured anti-PLA2R antibody in the
serum of 60 patients with idiopathic MN, 20 with lupus-associated MN, 16 with hepatitis B
(HBV)-associated MN, and 10 with tumor-associated MN. Among patients with idiopathic
MN, 49 (82%) had detectable anti-PLA2R autoantibodies using a Western blot assay; an …
membranous nephropathy (MN), but the prevalence of autoantibodies against PLA2R is
unknown among Chinese patients with MN. Here, we measured anti-PLA2R antibody in the
serum of 60 patients with idiopathic MN, 20 with lupus-associated MN, 16 with hepatitis B
(HBV)-associated MN, and 10 with tumor-associated MN. Among patients with idiopathic
MN, 49 (82%) had detectable anti-PLA2R autoantibodies using a Western blot assay; an …
