Autoantibodies targeting galactose-deficient IgA1 associate with progression of IgA nephropathy
F Berthoux, H Suzuki, L Thibaudin… - Journal of the …, 2012 - journals.lww.com
Mesangial and circulating IgA1 with aberrantly glycosylated hinge region O-glycans
characterize IgA nephropathy (IgAN). Unlike healthy individuals, some IgA1 is galactose
deficient in patients with IgAN, leaving terminal N-acetylgalactosamine residues in the hinge
region exposed. Circulating autoantibodies that recognize such galactose-deficient IgA1 as
an autoantigen, or the levels of the autoantigen itself, may allow prediction of disease
progression. Here, we analyzed serum samples obtained at diagnosis for autoantigen and …
characterize IgA nephropathy (IgAN). Unlike healthy individuals, some IgA1 is galactose
deficient in patients with IgAN, leaving terminal N-acetylgalactosamine residues in the hinge
region exposed. Circulating autoantibodies that recognize such galactose-deficient IgA1 as
an autoantigen, or the levels of the autoantigen itself, may allow prediction of disease
progression. Here, we analyzed serum samples obtained at diagnosis for autoantigen and …
