Understanding the epigenetic syntax for the genetic alphabet in the kidney
K Susztak - Journal of the American Society of Nephrology, 2014 - journals.lww.com
The cells in a human body have identical DNA sequences, yet the body has> 200 cell types
with different phenotypes. The basis for this nongenetic cellular memory, which records
developmental and environmental cues, is epigenetics. The epigenome includes covalent
modifications of the DNA and its associated proteins and defines DNA accessibility to the
transcriptional machinery. Notably, the epigenome has emerged as an important mediator of
the long-term programming effect of environmental exposure, and multiple lines of evidence …
with different phenotypes. The basis for this nongenetic cellular memory, which records
developmental and environmental cues, is epigenetics. The epigenome includes covalent
modifications of the DNA and its associated proteins and defines DNA accessibility to the
transcriptional machinery. Notably, the epigenome has emerged as an important mediator of
the long-term programming effect of environmental exposure, and multiple lines of evidence …
