p53 is renoprotective after ischemic kidney injury by reducing inflammation
TA Sutton, T Hato, E Mai, M Yoshimoto… - Journal of the …, 2013 - journals.lww.com
In the rat, p53 promotes tubular apoptosis after ischemic AKI. Acute pharmacologic inhibition
of p53 is protective in this setting, but chronic inhibition enhances fibrosis, demonstrating
that the role of p53 in ischemic AKI is incompletely understood. Here, we investigated
whether genetic absence of p53 is also protective in ischemic AKI. Surprisingly, p53-
knockout mice (p53−/−) had worse kidney injury, compared with wild-type mice, and
exhibited increased and prolonged infiltration of leukocytes after ischemia. Acute inhibition …
of p53 is protective in this setting, but chronic inhibition enhances fibrosis, demonstrating
that the role of p53 in ischemic AKI is incompletely understood. Here, we investigated
whether genetic absence of p53 is also protective in ischemic AKI. Surprisingly, p53-
knockout mice (p53−/−) had worse kidney injury, compared with wild-type mice, and
exhibited increased and prolonged infiltration of leukocytes after ischemia. Acute inhibition …
