[HTML][HTML] Mechanism of actin polymerization in cellular ATP depletion
SJ Atkinson, MA Hosford, BA Molitoris - Journal of Biological Chemistry, 2004 - ASBMB
Cellular ATP depletion in diverse cell types results in the net conversion of monomeric G-
actin to polymeric F-actin and is an important aspect of cellular injury in tissue ischemia. We
propose that this conversion results from altering the ratio of ATP-G-actin and ADP-G-actin,
causing a net decrease in the concentration of thymosinactin complexes as a consequence
of the differential affinity of thymosin β 4 for ATP-and ADP-G-actin. To test this hypothesis we
examined the effect of ATP depletion induced by antimycin A and substrate depletion on …
actin to polymeric F-actin and is an important aspect of cellular injury in tissue ischemia. We
propose that this conversion results from altering the ratio of ATP-G-actin and ADP-G-actin,
causing a net decrease in the concentration of thymosinactin complexes as a consequence
of the differential affinity of thymosin β 4 for ATP-and ADP-G-actin. To test this hypothesis we
examined the effect of ATP depletion induced by antimycin A and substrate depletion on …
