Regulation and intracellular trafficking pathways of the endothelin receptors
T Bremnes, JD Paasche, A Mehlum, C Sandberg… - Journal of Biological …, 2000 - ASBMB
The effects of endothelin (ET) are mediated via the G protein-coupled receptors ET A and ET
B. However, the mechanisms of ET receptor desensitization, internalization, and intracellular
trafficking are poorly understood. The aim of the present study was to investigate the
molecular mechanisms of ET receptor regulation and to characterize the intracellular
pathways of ET-stimulated ET A and ET B receptors. By analysis of ET A and ET B receptor
internalization in transfected Chinese hamster ovary cells in the presence of overexpressed …
B. However, the mechanisms of ET receptor desensitization, internalization, and intracellular
trafficking are poorly understood. The aim of the present study was to investigate the
molecular mechanisms of ET receptor regulation and to characterize the intracellular
pathways of ET-stimulated ET A and ET B receptors. By analysis of ET A and ET B receptor
internalization in transfected Chinese hamster ovary cells in the presence of overexpressed …
