[HTML][HTML] The inflammasome: first line of the immune response to cell stress
Y Ogura, FS Sutterwala, RA Flavell - Cell, 2006 - cell.com
Y Ogura, FS Sutterwala, RA Flavell
Cell, 2006•cell.comThe NALP3-inflammasome is a protein complex that stimulates caspase-1 activation to
promote the processing and secretion of proinflammatory cytokines. Recent work indicates
that the NALP3-inflammasome can be activated by endogenous" danger signals" as well as
compounds associated with pathogens (Kanneganti et al., 2006; Mariathasan et al., 2006;
Martinon et al., 2006; Sutterwala et al., 2006). Here, we discuss new insights into the
regulation of caspase-1 activity in the inflammatory response.
promote the processing and secretion of proinflammatory cytokines. Recent work indicates
that the NALP3-inflammasome can be activated by endogenous" danger signals" as well as
compounds associated with pathogens (Kanneganti et al., 2006; Mariathasan et al., 2006;
Martinon et al., 2006; Sutterwala et al., 2006). Here, we discuss new insights into the
regulation of caspase-1 activity in the inflammatory response.
The NALP3-inflammasome is a protein complex that stimulates caspase-1 activation to promote the processing and secretion of proinflammatory cytokines. Recent work indicates that the NALP3-inflammasome can be activated by endogenous "danger signals" as well as compounds associated with pathogens (Kanneganti et al., 2006; Mariathasan et al., 2006; Martinon et al., 2006; Sutterwala et al., 2006). Here, we discuss new insights into the regulation of caspase-1 activity in the inflammatory response.
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