The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion
A Flemming, T Brummer, M Reth, H Jumaa - Nature immunology, 2003 - nature.com
A Flemming, T Brummer, M Reth, H Jumaa
Nature immunology, 2003•nature.comMice deficient in the adaptor protein SLP-65 (also known as BLNK) have reduced numbers
of mature B cells, but an increased pre-B cell compartment. We show here that compared to
wild-type cells, SLP-65−/− pre-B cells show an enhanced ex vivo proliferative capacity. This
proliferation requires interleukin 7 and expression of the pre-B cell receptor (pre-BCR). In
addition, SLP-65−/− mice have a high incidence of pre-B cell lymphoma. Reintroduction of
SLP-65 into SLP-65−/− pre-B cells led to pre-BCR down-regulation and enhanced …
of mature B cells, but an increased pre-B cell compartment. We show here that compared to
wild-type cells, SLP-65−/− pre-B cells show an enhanced ex vivo proliferative capacity. This
proliferation requires interleukin 7 and expression of the pre-B cell receptor (pre-BCR). In
addition, SLP-65−/− mice have a high incidence of pre-B cell lymphoma. Reintroduction of
SLP-65 into SLP-65−/− pre-B cells led to pre-BCR down-regulation and enhanced …
Abstract
Mice deficient in the adaptor protein SLP-65 (also known as BLNK) have reduced numbers of mature B cells, but an increased pre-B cell compartment. We show here that compared to wild-type cells, SLP-65−/− pre-B cells show an enhanced ex vivo proliferative capacity. This proliferation requires interleukin 7 and expression of the pre-B cell receptor (pre-BCR). In addition, SLP-65−/− mice have a high incidence of pre-B cell lymphoma. Reintroduction of SLP-65 into SLP-65−/− pre-B cells led to pre-BCR down-regulation and enhanced differentiation. Our results indicate that SLP-65 regulates a developmental program that promotes differentiation and limits pre-B cell expansion, thereby acting as a tumor suppressor.
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