Exposure to bright light can cause visual dysfunction and retinal photoreceptor damage in
humans and experimental animals, but the mechanism (s) remain unclear. We investigated
whether the retinoid cycle (ie the series of biochemical reactions required for vision through
continuous generation of 11-cis-retinal and clearance of all-trans-retinal, respectively) might
be involved. Previously, we reported that mice lacking two enzymes responsible for clearing
all-trans-retinal, namely photoreceptor-specific ABCA4 (ATP-binding cassette transporter 4) …