[HTML][HTML] Interleukin-1β suppresses retinoid transactivation of two hepatic transporter genes involved in bile formation
LA Denson, KL Auld, DS Schiek, MH McClure… - Journal of Biological …, 2000 - ASBMB
Cytokines have been implicated in the pathogenesis of inflammatory cholestasis. This is due
to transcriptional down-regulation of hepatic transporters including the Na+/bile acid
cotransporter, ntcp, and the multispecific organic anion exporter, mrp2. We have recently
shown that ntcp suppression by lipopolysaccharidein vivo is caused by down-regulation of
transactivators including the previously uncharacterized Footprint B-binding protein. Both
the ntcp FpB element and the mrp2 promoter contain potential retinoid-response elements …
to transcriptional down-regulation of hepatic transporters including the Na+/bile acid
cotransporter, ntcp, and the multispecific organic anion exporter, mrp2. We have recently
shown that ntcp suppression by lipopolysaccharidein vivo is caused by down-regulation of
transactivators including the previously uncharacterized Footprint B-binding protein. Both
the ntcp FpB element and the mrp2 promoter contain potential retinoid-response elements …