[HTML][HTML] Intestinal FXR-mediated FGF15 production contributes to diurnal control of hepatic bile acid synthesis in mice
JHM Stroeve, G Brufau, F Stellaard, FJ Gonzalez… - Laboratory …, 2010 - Elsevier
Hepatic bile acid synthesis is subject to complex modes of transcriptional control, in which
the bile acid-activated nuclear receptor farnesoid X receptor (FXR) in liver and intestine-
derived, FXR-controlled fibroblast growth factor 15 (Fgf15) are involved. The Fgf15 pathway
is assumed to contribute significantly to control of hepatic bile acid synthesis. However,
scientific evidence supporting this assumption is primarily based on gene expression data.
Using intestine-selective FXR knockout mice (iFXR-KO), we show that contribution of …
the bile acid-activated nuclear receptor farnesoid X receptor (FXR) in liver and intestine-
derived, FXR-controlled fibroblast growth factor 15 (Fgf15) are involved. The Fgf15 pathway
is assumed to contribute significantly to control of hepatic bile acid synthesis. However,
scientific evidence supporting this assumption is primarily based on gene expression data.
Using intestine-selective FXR knockout mice (iFXR-KO), we show that contribution of …