Therapeutic strategy with a membrane-localizing complement regulator to increase the number of usable donor organs after prolonged cold storage

H Patel, RAG Smith, SH Sacks… - Journal of the American …, 2006 - journals.lww.com
A shortage of donor organs and increasing dependence on marginal grafts with prolonged
ischemic times have meant that new methods are needed to prevent postischemic damage.
Herein is reported a new strategy aimed to protect donor kidney from complement-mediated
postischemic damage and therefore increase the number of successful transplants. Rat
donor kidneys were perfused with a membrane-localizing complement regulator derived
from human complement receptor type 1 (APT070) and then subjected to prolonged periods …