Reduction of insulin resistance and plasma glucose level by salsalate treatment in persons with prediabetes
Objective To evaluate the effect of salsalate as an antiinflammatory agent on insulin
resistance and glycemic control in persons with prediabetes. Methods In this double-blind,
placebo-controlled clinical trial, 66 persons who had prediabetes on the basis of the
American Diabetes Association criteria were enrolled. They were randomly assigned to
receive salsalate (3 g daily) or placebo for 12 weeks. Fasting plasma glucose (FPG) and
insulin, glucose 2 hours after oral administration of 75 g of glucose, hemoglobin A 1c, lipid …
resistance and glycemic control in persons with prediabetes. Methods In this double-blind,
placebo-controlled clinical trial, 66 persons who had prediabetes on the basis of the
American Diabetes Association criteria were enrolled. They were randomly assigned to
receive salsalate (3 g daily) or placebo for 12 weeks. Fasting plasma glucose (FPG) and
insulin, glucose 2 hours after oral administration of 75 g of glucose, hemoglobin A 1c, lipid …