DEAD-box proteins: the driving forces behind RNA metabolism

S Rocak, P Linder - Nature reviews Molecular cell biology, 2004 - nature.com
S Rocak, P Linder
Nature reviews Molecular cell biology, 2004nature.com
RNA helicases from the DEAD-box family are found in almost all organisms and have
important roles in RNA metabolism. They are associated with many processes ranging from
RNA synthesis to RNA degradation. DEAD-box proteins use the energy from ATP hydrolysis
to rearrange inter-or intra-molecular RNA structures or dissociate RNA–protein complexes.
Such dynamic rearrangements are fundamental for many, if not all, steps in the life of an
RNA molecule. Recent biochemical, genetic and structural data shed light on how these …
Abstract
RNA helicases from the DEAD-box family are found in almost all organisms and have important roles in RNA metabolism. They are associated with many processes ranging from RNA synthesis to RNA degradation. DEAD-box proteins use the energy from ATP hydrolysis to rearrange inter- or intra-molecular RNA structures or dissociate RNA–protein complexes. Such dynamic rearrangements are fundamental for many, if not all, steps in the life of an RNA molecule. Recent biochemical, genetic and structural data shed light on how these proteins power the metabolism of RNA within a cell.
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