Distribution of glucagon-like peptide-1 immunoreactivity in the hypothalamic paraventricular and supraoptic nuclei

M Tauchi, R Zhang, DA D'Alessio, JE Stern… - Journal of chemical …, 2008 - Elsevier
Glucagon-like peptide-1 (GLP-1) plays a role in modulating neuroendocrine and autonomic
function. The hypothalamic paraventricular nucleus (PVN) contains aggregations of GLP-1
fibers and expresses GLP-1 receptors, making it a likely site of action for GLP-1 signaling.
The current study was designed to establish domains of GLP-1 action, focusing on
axosomatic appositions on different neuroendocrine and autonomic cell populations in the
PVN. The data indicate abundant GLP-1-immunoreactive terminal appositions on …