Natural Killer cell control of BRAFV600E mutant melanoma during targeted therapy

LF de Andrade, SF Ngiow, L Martinet… - Oncoimmunology, 2015 - Taylor & Francis
Oncoimmunology, 2015Taylor & Francis
Pharmacologic inhibition of the mutant BRAFV600E protein in advanced BRAFV600E
melanoma results in a high proportion of patients that respond, but few with durable
responses. We have recently revealed that Natural Killer (NK) cells play an essential role in
the BRAFV600E inhibitor control of melanoma metastases in mice that may be
therapeutically exploited to help overcome drug resistance.
Pharmacologic inhibition of the mutant BRAFV600E protein in advanced BRAFV600E melanoma results in a high proportion of patients that respond, but few with durable responses. We have recently revealed that Natural Killer (NK) cells play an essential role in the BRAFV600E inhibitor control of melanoma metastases in mice that may be therapeutically exploited to help overcome drug resistance.
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