RIPK1 protects hepatocytes from Kupffer cells-mediated TNF-induced apoptosis in mouse models of PAMP-induced hepatitis

A Filliol, C Piquet-Pellorce, C Raguénès-Nicol… - Journal of …, 2017 - Elsevier
Background & Aims The severity of liver diseases is exacerbated by the death of
hepatocytes, which can be induced by the sensing of pathogen associated molecular
patterns (PAMPs) derived from the gut microbiota. The molecular mechanisms regulating
these cell death pathways are poorly documented. In this study, we investigated the role of
the receptor interacting protein kinase 1 (RIPK1), a protein known to regulate cell fate
decisions, in the death of hepatocytes using two in vivo models of PAMP-induced hepatitis …