Two sodium channels contribute to the TTX-R sodium current in primary sensory neurons

S Tate, S Benn, C Hick, D Trezise, V John… - Nature …, 1998 - nature.com
S Tate, S Benn, C Hick, D Trezise, V John, RJ Mannion, M Costigan, C Plumpton, D Grose…
Nature neuroscience, 1998nature.com
We have cloned a second tetrodotoxin-resistant (TTX-R) sodium channel α subunit, SNS2,
with the same amino-acid sequence as a putative sodium channel α subunit NaN (ref. 1).
SNS2 expression in HEK293T cells produced a TTX-R voltage-gated sodium current with
faster kinetics and a lower TTX IC 50 than the previously cloned sensory-neuron-specific
sodium channel, SNS/PN3 (Refs 2, 3). SNS2 was co-expressed with SNS/PN3 in small DRG
neurons.
Abstract
We have cloned a second tetrodotoxin-resistant (TTX-R) sodium channel α subunit, SNS2, with the same amino-acid sequence as a putative sodium channel α subunit NaN (ref. 1). SNS2 expression in HEK293T cells produced a TTX-R voltage-gated sodium current with faster kinetics and a lower TTX IC 50 than the previously cloned sensory-neuron-specific sodium channel, SNS/PN3 (Refs 2, 3). SNS2 was co-expressed with SNS/PN3 in small DRG neurons.
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