Anti-human leukocyte antigen antibodies and preemptive antibody-directed therapy after lung transplantation
RR Hachem, RD Yusen, BF Meyers, AA Aloush… - The Journal of Heart and …, 2010 - Elsevier
BACKGROUND: Because the development of donor-specific anti-human leukocyte antigen
(HLA) antibodies (DSA) after lung transplantation has been associated with acute and
chronic rejection, we implemented a clinical protocol to screen all transplant recipients for
DSA and preemptively treat those who developed DSA with rituximab and intravenous
immune globulin (IVIG), or IVIG alone. METHODS: We conducted a prospective
observational study of this protocol and used the LABScreen Single Antigen assay to detect …
(HLA) antibodies (DSA) after lung transplantation has been associated with acute and
chronic rejection, we implemented a clinical protocol to screen all transplant recipients for
DSA and preemptively treat those who developed DSA with rituximab and intravenous
immune globulin (IVIG), or IVIG alone. METHODS: We conducted a prospective
observational study of this protocol and used the LABScreen Single Antigen assay to detect …