Detection of C3d-binding donor-specific anti-HLA antibodies at diagnosis of humoral rejection predicts renal graft loss
A Sicard, S Ducreux, M Rabeyrin, L Couzi… - Journal of the …, 2015 - journals.lww.com
Antibody-mediated rejection (AMR) is a major cause of kidney graft loss, yet assessment of
individual risk at diagnosis is impeded by the lack of a reliable prognosis assay. Here, we
tested whether the capacity of anti-HLA antibodies to bind complement components allows
accurate risk stratification at the time of AMR diagnosis. Among 938 kidney transplant
recipients for whom a graft biopsy was performed between 2004 and 2012 at the Lyon
University Hospitals, 69 fulfilled the diagnosis criteria for AMR and were enrolled. Sera …
individual risk at diagnosis is impeded by the lack of a reliable prognosis assay. Here, we
tested whether the capacity of anti-HLA antibodies to bind complement components allows
accurate risk stratification at the time of AMR diagnosis. Among 938 kidney transplant
recipients for whom a graft biopsy was performed between 2004 and 2012 at the Lyon
University Hospitals, 69 fulfilled the diagnosis criteria for AMR and were enrolled. Sera …