[HTML][HTML] Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6 [S]

R Tao, X Xiong, RA DePinho, CX Deng… - Journal of lipid research, 2013 - ASBMB
Cholesterol homeostasis is crucial for cellular function and organismal health. The key
regulator for the cholesterol biosynthesis is sterol-regulatory element binding protein
(SREBP)-2. The biochemical process and physiological function of SREBP-2 have been
well characterized; however, it is not clear how this gene is epigenetically regulated. Here
we have identified sirtuin (Sirt) 6 as a critical factor for Srebp2 gene regulation. Hepatic
deficiency of Sirt6 in mice leads to elevated cholesterol levels. On the mechanistic level …