Protective Capacity of Virus-Specific T Cell Receptor-Transduced CD8 T Cells In Vivo
K Mueller, A von Mässenhausen, U Aichele… - Journal of …, 2012 - Am Soc Microbiol
K Mueller, A von Mässenhausen, U Aichele, L Stärck, M Leisegang, W Uckert, H Pircher
Journal of virology, 2012•Am Soc MicrobiolThe transfer of T cell receptor (TCR) genes by viral vectors represents a promising technique
to generate antigen-specific T cells for adoptive immunotherapy. TCR-transduced T cells
specific for infectious pathogens have been described, but their protective function in vivo
has not yet been examined. Here, we demonstrate that CD8 T cells transduced with the P14
TCR specific for the gp33 epitope of lymphocytic choriomeningitis virus exhibit protective
activities in both viral and bacterial infection models in mice.
to generate antigen-specific T cells for adoptive immunotherapy. TCR-transduced T cells
specific for infectious pathogens have been described, but their protective function in vivo
has not yet been examined. Here, we demonstrate that CD8 T cells transduced with the P14
TCR specific for the gp33 epitope of lymphocytic choriomeningitis virus exhibit protective
activities in both viral and bacterial infection models in mice.
Abstract
The transfer of T cell receptor (TCR) genes by viral vectors represents a promising technique to generate antigen-specific T cells for adoptive immunotherapy. TCR-transduced T cells specific for infectious pathogens have been described, but their protective function in vivo has not yet been examined. Here, we demonstrate that CD8 T cells transduced with the P14 TCR specific for the gp33 epitope of lymphocytic choriomeningitis virus exhibit protective activities in both viral and bacterial infection models in mice.
American Society for Microbiology