[HTML][HTML] Limited redundancy of the proprotein convertase furin in mouse liver
AJM Roebroek, NA Taylor, E Louagie, I Pauli… - Journal of Biological …, 2004 - ASBMB
Furin is an endoprotease of the family of mammalian proprotein convertases and is involved
in the activation of a large variety of regulatory proteins by cleavage at basic motifs. A large
number of substrates have been attributed to furin on the basis of in vitro and ex vivo data.
However, no physiological substrates have been confirmed directly in a mammalian model
system, and early embryonic lethality of a furin knock-out mouse model has precluded in
vivo verification of most candidate substrates. Here, we report the generation and …
in the activation of a large variety of regulatory proteins by cleavage at basic motifs. A large
number of substrates have been attributed to furin on the basis of in vitro and ex vivo data.
However, no physiological substrates have been confirmed directly in a mammalian model
system, and early embryonic lethality of a furin knock-out mouse model has precluded in
vivo verification of most candidate substrates. Here, we report the generation and …
