Over time, there has been a shift in the paradigm of asthma, from a single-disease concept
toward a greater recognition of asthma as a complex, chronic disease with marked clinical
heterogeneity. Physicians have long suspected that patients with asthma belong to
phenotypes based on observed differences in clinical presentation and response to therapy.
The study of asthma phenotypes is evolving, with increased investigation into their genetic
underpinnings and corresponding biomarkers. Until the past decade or so, limited …