Understanding HIV latency: the road to an HIV cure
MS Dahabieh, E Battivelli, E Verdin - Annual review of medicine, 2015 - annualreviews.org
MS Dahabieh, E Battivelli, E Verdin
Annual review of medicine, 2015•annualreviews.orgTreatment with antiretroviral therapy dramatically increases the survival of HIV-infected
individuals. However, treatment has to be continued for life because it does not lead to the
full eradication of infection. HIV persists in resting CD4+ T cells, and possibly other cell
types, and can reemerge from these cells when therapy is interrupted. Here, we review
molecular mechanisms that have been proposed to contribute to HIV latency, as well as the
relative roles of cis-and trans-acting mechanisms. We also discuss existing and future …
individuals. However, treatment has to be continued for life because it does not lead to the
full eradication of infection. HIV persists in resting CD4+ T cells, and possibly other cell
types, and can reemerge from these cells when therapy is interrupted. Here, we review
molecular mechanisms that have been proposed to contribute to HIV latency, as well as the
relative roles of cis-and trans-acting mechanisms. We also discuss existing and future …
Treatment with antiretroviral therapy dramatically increases the survival of HIV-infected individuals. However, treatment has to be continued for life because it does not lead to the full eradication of infection. HIV persists in resting CD4+ T cells, and possibly other cell types, and can reemerge from these cells when therapy is interrupted. Here, we review molecular mechanisms that have been proposed to contribute to HIV latency, as well as the relative roles of cis- and trans-acting mechanisms. We also discuss existing and future therapeutic opportunities regarding HIV latency that might lead to a future cure for HIV infection.
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